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Some of the Available Modifications

Non-fluorescent modifications

Type of modification

Price per insertion,
100 or 200 nmole scale

Price per insertion, 
1000 nmole scale

Degenerated bases 
(equimolar mix)

$0.00

$0.00

Degenerated bases 
(non-equimolar mix, also
known as "doping")

US$3 / CAN$3

US$9 / CAN$9

2'-O-Me RNA

US$6 / CAN$6

US$12 / CAN$12

5' Acrydite

US$60 / CAN$60

US$180 / CAN$180

Inosine (deoxyinosine, dI)

US$6.67 / CAN$6.67

US$16 / CAN$16

Uridine (deoxyuridine, dU)

US$6.67 / CAN$6.67

US$16 / CAN$16

5' Phosphorylation

US$20 / CAN$20

US$40 / CAN$40

3' Phosphorylation

US$15 / CAN$15

US$30 / CAN$30

5' Amine

US$14 /CAN$14

US$28 / CAN$28

3' Amine

US$15 / CAN$15

US$30 / CAN$30

5' Thiol

US$40 / CAN$40

US$80 / CAN$80

3' Thiol

US$25 / CAN$25

US$50 / CAN$50

5' Biotin

US$29 / CAN$29

US$78 / CAN$78

3' Biotin

US$25 / CAN$25

US$50 / CAN$50

5' Cholesterol

1 insertion/order

2 insertions/order

3 or more insertions/order

 

US$200 / CAN$200

US$110 / CAN$110

US$80 / CAN$80

 

US$400 / CAN$400

US$220 / CAN$220

US$160 / CAN$160

3' Cholesterol

US$70 / CAN$70

US$140 / CAN$140

Spacer C3 (5', 3' or internal)

US$40 / CAN$40

US$80 / CAN$80

5' Digoxigenin

US$120 / CAN$120

US$240 / CAN$240

3' Digoxigenin

US$120 / CAN$120

US$240 / CAN$240

Fluorescent dye modifications, for oligos

without a quencher (single-label probes)

(for Real-Time PCR / dual-label probes click here)

Type of modification

Price per insertion,
100 or 200 nmole scale

Price per insertion, 
1000 nmole scale

5' Fluorescein

(for Real-Time PCR probes click here)

US$24 / CAN$24

US$50 / CAN$50

3' Fluorescein

US$25 / CAN$25

US$50 / CAN$50

5'-end 6-FAM, HEX or TET 

(for Real-Time PCR probes click here)

US$29 / CAN$29

US$75 / CAN$75

3'-end 6-FAM, HEX or TET 

US$49 / CAN$49

US$149 / CAN$149

5' VIC-replacement dye

(for Real-Time PCR probes click here)

US$29 / CAN$29

US$150 / CAN$150

3' VIC-replacement dye

US$29 / CAN$29

US$150 / CAN$150

5' NED-replacement dye

(for Real-Time PCR probes click here)

US$29 / CAN$29

US$150 / CAN$150

3' NED-replacement dye

US$29 / CAN$29

US$150 / CAN$150

5' PET-replacement dye

(for Real-Time PCR probes click here)

US$29 / CAN$29

US$150 / CAN$150

3' PET-replacement dye

US$29 / CAN$29

US$150 / CAN$150

5' LIZ-replacement dye

(for Real-Time PCR probes click here)

US$29 / CAN$29

US$150 / CAN$150

3' LIZ-replacement dye

US$29 / CAN$29

US$150 / CAN$150

5' JOE-replacement dye

(for Real-Time PCR probes click here)

US$29 / CAN$29

US$150 / CAN$150

3' JOE-replacement dye

US$29 / CAN$29

US$150 / CAN$150

5' ROX-replacement dye

(for Real-Time PCR probes click here)

US$29 / CAN$29

US$150 / CAN$150

3' ROX-replacement dye

US$29 / CAN$29

US$150 / CAN$150

3' BHQ-1(black hole quencher)

US$50 / CAN$50

US$100 / CAN$100

3' BHQ-2

US$50 / CAN$50

US$100 / CAN$100

3' BHQ-3

US$50 / CAN$50

US$100 / CAN$100

3' MGB (minor groove binder)

US$95 / CAN$128

US$285 / CAN$384

3' Dabcyl

US$49 / CAN$49

US$99 / CAN$99

5' TAMRA

(for Real-Time PCR probes click here)

US$29 / CAN$29

US$150 / CAN$150

3' TAMRA

US$49 / CAN$49

US$149 / CAN$149

5' Rhodamine (=NHS-Rhodamine

may replace TAMRA and NED)

US$29 / CAN$29

US$150 / CAN$150

3' Rhodamine (=NHS-Rhodamine

may replace TAMRA and NED)

US$29 / CAN$29

US$150 / CAN$150

5' Rhodamine Green

(may replace Oregon Green 514,

or Alexa Fluor 500)

US$80 / CAN$80

US$240 / CAN$240

3' Rhodamine Green

(may replace Oregon Green 514,

or Alexa Fluor 500)

US$80 / CAN$80

US$240 / CAN$240

5' Rhodamine Red

US$80 / CAN$80

US$240 / CAN$240

3' Rhodamine Red

US$80 / CAN$80

US$240 / CAN$240

3' Eclipse

US$70 / CAN$70

US$199 / CAN$199

5' Cy3 dye

(may replace Quasar 570)

(for Real-Time PCR probes click here)

US$29 / CAN$29

US$150 / CAN$150

3' Cy3 dye

US$29 / CAN$29

US$150 / CAN$150

5' Cy3.5 dye

(for Real-Time PCR probes click here)

US$29 / CAN$29

US$150 / CAN$150

3' Cy3.5 dye

US$29 / CAN$29

US$150 / CAN$150

5' Cy5 dye

(may replace WellRed D4,

LC Red 670, Quasar 670)

(for Real-Time PCR probes click here)

US$29 / CAN$29

US$150 / CAN$150

3' Cy5 dye

(may replace D4, LC Red 670,

Quasar 670)

US$29 / CAN$29

US$150 / CAN$150

5' Cy5.5 dye

(may replace IRD 700, Quasar 705,

WellRed D3 and LC-Red 705)

(for Real-Time PCR probes click here)

US$29 / CAN$29

US$150 / CAN$150

3' Cy5.5 dye

(may replace IRD 700,

WellRed D3, Quasar 705,

and LC-Red 705)

US$29 / CAN$29

US$150 / CAN$150

5' Quasar 705 dye

(may replace IRD 700,

D3 and LC-Red 705)

(for Real-Time PCR probes click here)

US$80 / CAN$80

US$240 / CAN$240

5' Cy7 dye

US$29 / CAN$29

US$150 / CAN$150

3' Cy7 dye

US$29 / CAN$29

US$150 / CAN$150

5' Cy7.5 dye

US$29 / CAN$29

US$150 / CAN$150

3' Cy7.5 dye

US$29 / CAN$29

US$150 / CAN$150

5' Texas Red

(may replace PET, ROX, Cy3.5,

Redmond Red, LC Red 610)

(for Real-Time PCR probes click here)

US$29 / CAN$29

US$150 / CAN$150

3' Texas Red

(may replace PET, ROX, Cy3.5,

Redmond Red, LC Red 610)

US$29 / CAN$29

US$150 / CAN$150

5' Cal Fluor Red 610 (may replace

Texas Red, PET, ROX or Cy3.5)

(for Real-Time PCR probes click here)

US$80 / CAN$80

US$240 / CAN$240

5' Cal Fluor Red 635 (may replace

LC-Red 640)

US$80 / CAN$80

US$240 / CAN$240

5' LC Red 610 replacement dye

US$29 / CAN$29

US$150 / CAN$150

3' LC Red 610 replacement dye

US$29 / CAN$29

US$150 / CAN$150

5' LC Red 640 replacement dye

US$80 / CAN$80

US$240 / CAN$240

3' LC Red 640 replacement dye

US$80 / CAN$80

US$240 / CAN$240

5' LC Red 670 replacement dye

US$29 / CAN$29

US$150 / CAN$150

3' LC Red 670 replacement dye

US$29 / CAN$29

US$150 / CAN$150

5' LC Red 705 replacement dye

US$29 / CAN$29

US$150 / CAN$150

3' LC Red 705 replacement dye

US$29 / CAN$29

US$150 / CAN$150

5' IRD 700-replacement dye

(for Real-Time PCR probes click here)

US$29 / CAN$29

US$150 / CAN$150

3' IRD 700-replacement dye

US$29 / CAN$29

US$150 / CAN$150

5' IRD 800-replacement dye

US$29 / CAN$29

US$150 / CAN$150

3' IRD 800-replacement dye

US$29 / CAN$29

US$150 / CAN$150

5' WellRed D2-replacement dye

US$29 / CAN$29

US$150 / CAN$150

3' WellRed D2-replacement dye

US$29 / CAN$29

US$150 / CAN$150

5' WellRed D3-replacement dye

(for Real-Time PCR probes click here)

US$29 / CAN$29

US$150 / CAN$150

3' WellRed D3-replacement dye

US$29 / CAN$29

US$150 / CAN$150

5' WellRed D4-replacement dye

(for Real-Time PCR probes click here)

US$29 / CAN$29

US$150 / CAN$150

3' WellRed D4-replacement dye

US$29 / CAN$29

US$150 / CAN$150

5' Yakima Yellow

(for Real-Time PCR probes click here)

US$120 / CAN$120

US$300 / CAN$300

3' Yakima Yellow

US$80 / CAN$80

US$140 / CAN$140

5' Alexa Fluor 350-replacement

US$80 / CAN$80

US$240 / CAN$240

3' Alexa Fluor 350-replacement

US$80 / CAN$80

US$240 / CAN$240

5' Pacific Blue-replacement

US$80 / CAN$80

US$240 / CAN$240

3' Pacific Blue-replacement

US$80 / CAN$80

US$240 / CAN$240

5' AMCA (amino-methyl-coumarin)

US$29 / CAN$29

US$100 / CAN$100

3' AMCA (amino-methyl-coumarin)

US$29 / CAN$29

US$100 / CAN$100

5' Redmond Red (may replace

TxRed, PET, ROX or Cy3.5)

(for Real-Time PCR probes click here)

US$80 / CAN$80

US$240 / CAN$240

3' Redmond Red (may replace

TxRed, PET, ROX or Cy3.5)

US$80 / CAN$80

US$240 / CAN$240

Other modifications (such as 
internal dye modifications,
 
BHQ-dT, biotin-dT, amino-dT, 
Spacers, 8-Br-dG, 5-Me-dC, etc.)

Please inquire

Please inquire

Discounts for more than 
one oligo with the same 
type of modification

Please inquire

Please inquire

The 200 nmole (0.2 micromole) synthesis scale would typically yield 0.1-0.2 micromole (100-200 nmole) final product.  Guaranteed minimum 50 nmole (shorter oligos) or 12 OD units (longer oligos), desalted, non-modified oligos, ordered at the 200 nmole synthesis scale.  Standard purity includes free desalting.  Modified and additionally purified oligos may have lower yields.  All oligos are quantified and three different units of measure are provided to the customer.  The exact relation between these three units is calculated by a computer for each oligo; as a very rough approximation for a 20 base long oligo, 100 nmole equals approx. 20 OD260 units, or 600 micrograms.  Example of price calculation for one oligonucleotide, 20-mer, 100 nmole scale, 5'-end labeled with 6-FAM:  20 x 0.29 = 5.80 basic price of the oligo, plus 29.00 for the 6-FAM, total = 34.80 USD.  We would like to suggest using our special order form in Microsoft Excel format, please e-mail us your request for the form (the forms are not available for download from this site, because they differ by country/province, language etc.). The order form will automatically calculate the price of each oligo, including most modifications, and the total for your order.

The prices in Canadian dollars are valid only for customers from Canada, and are subject to government sales taxes (GST, HST, QST).  The taxes are extra (not included in the above prices).

Phosphorothioated oligonucleotides (PTO)

Synthesis scale

Additional charge per PTO base

Basic cost per base

Setup charge

0.2 μmole

US$1.50 / CAN$1.50 per PTO base

US$0.39 / CAN$0.39

$0.00

1.0 μmole

US$1.50 / CAN$1.50 per PTO base

US$0.79 / CAN$0.79

$0.00

15 μmole

US$10.00 / CAN$10.00 per PTO base

US$6.50 / CAN$6.50

US$30 / CAN$30

Example: One oligo of 20 bases at the 200 nmole scale, of which 3 backbone links at each end are phosphorothioated:  20 x 0.39 = 7.80, plus (3+3) x 1.50 = 9.00, for the total of 16.80.  Please use asterisks to describe the phosphorothioated backbone links, for example A*T*C*AGTGACTCGTAGTG*C*T*A

The prices in Canadian dollars are valid only for customers from Canada, and are subject to government sales taxes (GST, HST, QST).  The taxes are extra (not included in the above prices).


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